HOUSTON – THE COUNTDOWN HAS BEGUN
Just a short IMMUNOTHERAPY CLINICAL TRIAL update post today-
The phone call just came in last night: The Clinical Trial Countdown Clock has officially started!
As a reminder, here is the Phase 1b trial I will be participating in: “Phase I Study of Enadenotucirev and PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial Tumors (SPICE)” (NCT02636036)
The pre-trial process at City of Hope Cancer Center up in LA will start on Feb. 1st (biopsies, scans etc) – so I will be commuting back and forth a number of times in the month of February for that pre-trial prep work.
Then at the end of the month, we’ll have launch! Three infusions of TRILLIONS of genetically engineered oncolytic viruses specifically aimed at my CRC tumors will happen on Monday 2/27, Wednesday 3/1, and Friday 3/3!
PD1 inhibitor immunotherapy infusions will start shortly thereafter.
I won’t recap all the science again (see the link below where I discussed it in October) – but in general terms… The oncolytic virus is intended to: preferentially replicate in CRC tumor tissue; break down that tissue; catch the immune system’s attention (viruses are very good at that!), make the tumors highly inflamed (i.e. convert immunologically cold MSS-CRC tumors into “hot” tumors), and increase immune T-cell infiltration into the tumors.
Then once the tumors are inflamed and have T-cell infiltration… hit them with PD-1 inhibitor immunotherapy to release the brakes…
The more complete story from October on what exactly this trial is and why I am doing it is at this link! MY VERY OWN CITY OF HOPE: MSS-CRC CLINICAL TRIAL #1
Time to take my first swing for the fences – it may or may not be the game winning swing (there is a good chance I might need more than one) but there has to be a first!
I’m thrilled the countdown to trial start has finally started!