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Cover photo by Ariana Drehsler for STAT.  Source: STAT News – here. As you know I work with MANY different CRC organizations – The WunderGlo Foundation, Fight Colorectal Cancer, COLONTOWN, The Colon Club, the Colon Cancer Alliance etc – all are doing many great advocacy (and in the case of WunderGlo a purely CURE RESEARCH focus) projects in their own way. Because I work for so many – fundraising would get very… Read More

There is something deeply visceral about your brain… It is the center of thought… It is the center of your being… it is the center of who you are… All of those aspects of the brain came crashing down around me late last week.  I had gotten a PET-CT scan to see how my disease was responding to my current therapy and there was a surprise. A bad surprise.  There was a bright… Read More

Both psychologically and practically it is interesting how a cancer patient’s attitude and approach to chemotherapy changes over the course of a “Cancer Career”.  That is a phrase that just popped into my mind recently… “Cancer Career”.  I am fast approaching the 5-year anniversary of my metastatic cancer diagnosis (June 4, 2012).  5 years, starting when I was 40 years old.  Considering that my adult life started when I was 22 (I… Read More

Wow. What an incredible week it has been… I am tearing up now just thinking about it as I fly home from New York City (NYC) to my home and my family in San Diego. A lot of people have been wondering how I have been doing since the last medical update (In Case of Emergency Break Glass).  It is hard to believe that it has been almost a month since that… Read More

March 1st is the beginning of Colorectal Cancer Awareness month. I chose to commemorate it in this way – in the hopes that these pictures will bring awareness of the EXPLOSION in early-onset CRC cases. If you have GI symptoms with more common causes ruled out by your PCP – NO MATTER WHAT YOUR AGE – demand a colonoscopy! If I had been faster, I might not be Stage IV right now…. Read More

Well… a blog post I certainly don’t want to write and I did not plan on writing… I was told to never bury the lead of a story – so here it is: My oncolytic virus clinical trial plans have been canceled (hopefully just postponed). What? How?? Why??? I assure you the decision was not made lightly but it is also a decision I am 100% comfortable was the correct one to… Read More

As readers of this blog know, physically I have been going through a rough patch the past 6 weeks or so.  Thankfully, something that is now changing! The sudden ramp up of pain right before Christmas that I have written about which impacted me and my entire family physically, mentally and emotionally, the recent loss of a close friend  and the endurance of a round of radiotherapy the past three weeks, which was… Read More

What invigorates me to fight the way I do?  Well beyond basic self-preservation for both me and for my family – it is the sheer amount of needless loss I see on a frequent basis.  Losses in the world of my fellow cancer patients, including close friends and including on some days, very special friends. A very special friend of mine died of early-onset CRC yesterday. Alex was only 26, diagnosed 15… Read More

Just a short IMMUNOTHERAPY CLINICAL TRIAL update post today- The phone call just came in last night: The Clinical Trial Countdown Clock has officially started! As a reminder, here is the Phase 1b trial I will be participating in: “Phase I Study of Enadenotucirev and PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial Tumors (SPICE)” (NCT02636036) The pre-trial process at City of Hope Cancer Center up in LA will start on Feb…. Read More

An incredibly intense series of events have been happening to me medically over the past month – life changing events for both me and my family.  Things were happening so quickly, I haven’t been able to provide updates here – but today I’ll change that.  Today, you will hear what has been going on.   It was a rough month – for both me and my entire family – but I am honestly… Read More

I had hoped to start 2017 out with a full personal update blog post but there are so many intertwined parts currently in motion (and things currently unclear being clarified!), that a full post will have to wait for just a bit longer!  It has been a very hectic & significant past few weeks and I think January will follow suit.  As always, follow my (public) Facebook feed if you want more… Read More

I feel so extraordinary, Something’s got a hold on me I get this feeling I’m in motion, A sudden sense of liberty… I used to think that the day would never come, I’d see delight in the shade of the morning sun “In many ways 2015 was the most incredible year of my life.  Over 3 years into a currently incurable Stage IV colon cancer diagnosis, that phrase says a lot.” That… Read More

This is a blog post I had been hoping to write for a long time! The first published (today in the New England Journal of Medicine) “clinically disease free” success achieved via immunotherapy & surgery in an advanced Stage IV patient with the common “Microsatellite Stable (MSS)” subtype of colorectal cancer (CRC) – the kind of CRC that I and most CRC patients have! As of right now it is only a… Read More

SCHEDULED FOR FRIDAY (12/23) – NBC NATIONAL NIGHTLY NEWS with Lester Holt!  NBC Nightly News recently interviewed both I and a patient/caregiver couple helped by the COLONTOWN CLINIC, a project supported by the Colon Cancer Alliance.  The interview and story will air this ????? night. As many of you know, I am proud to work on numerous patient Clinical Trial advocacy efforts with a number of advocacy organizations to try to empower &… Read More

In the immortal words of our most recent Nobel Prize Laureate Bob Dylan , the times they are a changin’…  This morning I will be having my final Full Fury (FOLFIRI) chemo infusion for the foreseeable future.  A chemo cocktail that I first had the joy of encountering way back in 2012, and after restarting it, have been doing continuously (minus some #CannonballLife breaks) for the past 12 months.  Restarting FOLFIRI last… Read More

Cobimetinib  + Atezolizumab  might have grabbed all the Microsatellite Stable-Colorectal Cancer (MSS-CRC) immunotherapy headlines in 2016 but quietly in the background was a second published/presented  Phase 1 Immunotherapy Clinical Trial with preliminary signs of activity in MSS-CRC patients.  I suspect it slipped under the medical radar earlier this year because its Phase 1 Clinical Trial results and related preclinical data were published in a (albeit very good!) scientific journal (Cancer Cell) rather… Read More

Pain. I’ve been very fortunate over the past over 4 ½ years since my cancer diagnosis.  I had some pain immediately before my diagnosis from my primary tumor but ever since that surgery in June 2012, I have lived a pain-free life.  Except for an occasional cough in-between treatment regimens, zero symptoms of cancer. Sure I have chemo side effects to deal with, especially when I switched over to Full Fury (oops… Read More

When you are first diagnosed with cancer, many things stream through your mind at light speed.  Being there for your kids, impending major changes to lifestyle and life plans, and right up there in that top tier of thoughts are worries about your employment and workplace. Before I drill down to my specifics, these are HUGE concerns impacting Stage IV patients overall, adding yet additional layers of stress on top of their… Read More

As long time readers of my blog know – I have been in a quandary since I was diagnosed with (presumably cured) Stage 1 melanoma in January 2015.  That diagnosis, even though presumably cured by simple day surgery, with zero signs of recurrence ever since e.g. by monitoring with blood liquid biopsy, effectively blocked me from most colorectal cancer (CRC) clinical trials. Without clinical trials there is statistically an essentially 100% chance… Read More

This is a lengthy science post I have been debating whether to write for over a year.  Many fellow patients have been asking me to write it but I have hesitated.  Why debated? Why hesitated? At the root of ANY science post I write, I have to believe in my heart that the possibility of harm is vastly outweighed by the possibility of good that could come about by me sharing my… Read More

Photo graphic courtesy of STAT News, Photo by James Cuevas I hear questions all the time for an update on my personalized “neoantigen” immunotherapy research project – a project I first wrote about in blog format last February. If you want to know a broader view (both historical background and current status) about our quest to cure both my own MSS-CRC & efforts to lead the way for fellow MSS colorectal cancer patients as… Read More

My latest column for the Philadelphia Inquirer newspaper published today.  I continue to be very thankful that they have given me an outlet for both sharing aspects of Stage IV cancer life to the general public as well as for me to publish creative writing (which I LOVE doing, I seriously look forward to writing these columns about every 2 weeks!).  BTW I now has an updated page on my blog with all my Philadelphia… Read More

Hope – it is such a simple, yet complex word. A short word that is easy to explain on the base-level but it can be incredibly complex to comprehend all the facets in which it can impact the human psyche. Hope can be rational or irrational – the human brain has trouble distinguishing.  Are we paralyzed in fear that we will not be alive for the next major Holiday?  No – we… Read More

I had my post-summer-chemo-break CT-scan on Wednesday.  Regrets & worry started to try to enter my consciousness.  They were unwelcome invaders and to be honest, rarely seen or felt in my psyche now days.  But here they were – as I laid on the CT-scan table getting scanned…. Laying there completely alone, unlike the constant buzz of comradery that had surrounded me throughout my summer. A scan to quantify how much my… Read More

Friends. Family. Brothers. Sisters. Those words get used a lot in my current Stage IV life and they’re not necessarily referring to the people you would expect.  They’re referring to fellow cancer patients and survivors, often especially those also with Stage IV disease. There is a special bond between fellow cancer patients and survivors that is the deepest bond outside of nuclear family I have ever seen. In general, friends are brought… Read More

The CT-guided lung biopsy mentioned in my previous post was completed today at the University of Michigan without complications! It is intended to provide both DNA and RNA sequencing data for my personalized immunotherapy project – so I was bouncing with excitement when I entered the CT-scanning room this morning. I was surprised on the table to find out I would be wide awake for the entire procedure.  That + starting to picture the… Read More

What do you do when two fully qualified major medical centers give you opposite medical advice?  What do you do when the decision impacts your personal colorectal cancer (CRC) immunotherapy research and shot at a cure?  Today, I want to provide a medical update related to my personalized immunotherapy research project but while doing that, also discuss a major issue which impacts many cancer patients, myself included, conflicting medical advice. ‘Ask your… Read More

This post is primarily for Stage IV colorectal (CRC) survivor and caregiver readers (and indirectly for Stage IV lung cancer readers as well, see below!): An interview with a Dr. Johanna Bendell, a Principal Investigator of the MSS-CRC immunotherapy breakthrough clinical trial which combined a MEK inhibitor (Cobimetinib) with a PD-L1 inhibitor (Atezolizumab).  This clinical trial data was presented at ASCO-2016 by Dr. Bendell, a clinical trial expert. I have never done four posts… Read More

I just wanted to give a brief personal medical update and my related summer plans! With the exception of my diagnosis summer (2012) when potentially curative chemo was given ASAP, I have always had the “goal” (when medically possible) to take summers off from treatment.  Even though I am terminally optimistic, I am also realistic… part of Stage IV life is thinking through the memories you are generating for your kids –… Read More

Last year I was lucky enough to be chosen as a Featured Survivor in the annual Colondar 2.0 magazine  that The Colon Club produces each year. As a part of being chosen, you are invited to attend a “Colon Camp” retreat in rural Tennessee.  Last year I wrote in the post “ELEVEN NEW SISTERS AND BROTHERS (AND MANY MORE COUSINS)”, that going to Colon Camp last June was an amazing life-changing experience for me. … Read More

To complete the trilogy of posts on the major new preliminary MSS Colorectal Cancer (CRC) immunotherapy results released today on the combination therapy of the MEK inhibitor cobimetinib + the PDL1 inhibitor atezolizumab, I’m excited to share the data released at ASCO-2016 this morning!  Both drugs are already FDA approved for other types of cancer – this was the first examination of their combined use against MSS-CRC. When dosed alone, neither MEK… Read More

Today is my fourth cancerversary – my first diagnosis of colorectal cancer (CRC) was June 4, 2012.  I have already talked about my upbeat feelings on cancerversaries in previous years’ blog posts and letters to friends & families, as I gratefully celebrated another year of living after a lot of unknowns (!) at the time of diagnosis… so I won’t repeat those again today. I invite you to read a complete summary… Read More

I usually only do this kind of “real-time trial news” post on my Facebook or Twitter accounts but this is such BIG news, I wanted to publish here as well to spread the word to the colorectal cancer (CRC) patient & caregiver portion of my Blog readership. A PHASE 3 Immunotherapy Clinical Trial was registered today – including for MSS-CRC, the major type of CRC (95% of Stage IV) and the type… Read More

As I promised in my last post “Czech Please!” it is now ASCO season, so be prepared for a science post…  This one is a little hardcore – but bear with me, I tried to keep unessential scientific details to a minimum and as the title indicates (major spoiler alert!), I think it has a very important message! One, with my eyes misting up a bit, I have been yearning to write… Read More

When I first started this blog, I made a very conscious decision: I wanted to “be that Google Hit” found when someone first diagnosed with CRC is scrambling to search for information in the middle of the panic of recent diagnosis.  Patients panicking while looking at survival stats, in need of HOPE.  Following the extremely good role models of the two blogs that performed that role for me during my own diagnosis… Read More

A great aspect of my current life is that I get to meet some incredible people doing incredible things.  Doing things that they never would have done without cancer entering their life – done both in spite of cancer and because of it. Many of these people are incredible in quiet and unassuming ways.  Others make big impacts in more public sorts of way.  Lee Silverstein is in the latter group. I… Read More

A very brief medical update! Being hit by a FOLFIRI chemo infusion today only 48 hours after running the team triathlon truly feels bizarre… But that is one of the crazy aspects of Stage IV life! You swing from doing the absolutely “normal” (commuting to work, dinner out with the family) to being knocked out in an infusion chair and crawling into bed “bowl handy” as soon as you get home afterwards…… Read More

My alarm went off at 3:30 this morning.  I was not expecting what ended up being my first thoughts.  They weren’t of me running the run leg of this morning’s Spring Sprint Team Triathlon per se.  Instead, intermingled with run thoughts were also thoughts of fellow colorectal cancer (CRC) survivors I know who currently aren’t doing too well. Survivors I know that aren’t physically able to run right now. Those were the… Read More

Part of my current life is focusing on the here and now.  Living in the moment.  This is not a bad way to live life.  Yesterdays are just that… yesterdays – fixed in time, unchangeable – never to return.  Tomorrows are also just that… tomorrows – unknown – filled with possibilities but never guaranteed.  None of us knows if we will be here tomorrow. In many ways I have appreciated living in… Read More

Surfing the AACR Waves of Science What a day.  I just woke up from a drug-induced nap that wasn’t particularly long but it was deep.  For the second FOLFIRI chemo infusion in a row, I fell into such a deep sleep when I got home, that when I woke up it felt like I had slept for many hours.  Looking over at the clock, it said 4:37.  That felt about right –… Read More

As a mirror to my post in February called “One Little Number”, I wanted to write a very short post tonight called “The (Positive) Power of One Little Number”  It shows the wild-emotional swings of Stage IV cancer – as you careen back and forth between positive and negative data. The number referred to in both posts is the blood tumor marker: Carcinoembryonic antigen (CEA).  It is usually monitored during Stage IV colorectal… Read More

It’s hard to believe that it has already been almost 12 months since I last ran a UCSD-Moores Cancer Center Team Triathlon, which I wrote about last year in my post THE ULTIMATE TEAM SPORT: “A big part of being a cancer patient is trying your hardest to not give up in the face of adversity.  In that way it is very similar to endurance sports.  This is what makes the Moores… Read More

In conjunction with the start of Colorectal Cancer (CRC) awareness month, I’m excited to announce that the 2016 Colondar 2.0 annual resource magazine was released today! I LOVE the page from my section pictured above (all Colondar 2.0 photos taken by the incredible Mark McCarty & courtesy of The Colon Club!).  Note the caption they chose to use, I think they captured my mindset and philosophy perfectly. “Incurable… For now… The lung spots… Read More

To begin with, my CT scan was good – my tumors are shrinking from the FOLFIRI + Avastin chemotherapy I am currently taking!  I have had a 4 week break – the side effects go away after 3 weeks, so I even recently snuck in a 10k run! 🙂 I will be continuing to take chemo biweekly for now.  But that is a battle win (which I am very happy for!!) –… Read More

My friend Lindsey Motley died of colorectal cancer (CRC) today.  She was 29 years old. She was very special in many ways to an incredibly large number of people – including to me. Lindsey was many things…  Too many things to list to do justice.  I think most of all she was a loving wife and mother to a young daughter. At the end of the day what matters more than that?… Read More

La version en Español es accesible pasando el texto original en Inglés The title of this post is “The Faces of Successful Colorectal Cancer Immunotherpies: Vol. 1” in Spanish.  To explain why… Uniting the Western Hemisphere A major goal of mine is to bring this blog’s message of scientific information, positive Stage IV life outlook and in both cases HOPE to the different corners of the world.  Continuing this goal, following successful… Read More

“Each patient’s cancer is unique and personalized – why shouldn’t their treatment be too?” My latest The Currently Incurable Scientist column for Fight Colorectal Cancer has published and it ended with the above quote.  The column discusses an area of cutting edge oncology research that I find absolutely fascinating: a type of experimental immunotherapy called a “personalized cancer vaccine”.  I already mentioned personalized immunotherapies briefly in my post “My New Year’s Vision of… Read More

A year ago this week, I wrote my first-ever blog post “Taking the Latest Treatment Plunge” while on a first-ever family ski vacation celebrating Eleni’s 4th birthday in Park City, UT.  It was a time period with a lot of unknowns. My maintenance chemo (5-FU + Avastin) was failing and I was entering 2015 with a lot of medical and treatment uncertainties while fighting against the fear of the unknown. Would I… Read More

To start off year #2 of my blog and to kick off the New Year, instead of looking back (I did that with my recent post “World in My Eyes (Favorite Posts of 2015”) – I decided to look forward. And look forward in a positive but also provocative and perhaps controversial way. Making bold predictions in science is often considered a fool’s errand.  Science is all about exploring the unknown, attempting… Read More

Everyone who reads this blog knows how much running is tied into my cancer story.  From its very beginnings as initially a fast-paced walk during my Stage 3 NED (No Evidence of Disease) days, to my first ever half-marathon length run the same day a PET-CT scan showed probable recurrence/Stage IV, to my post-Stage IV diagnosis team triathlons with the UCSD-Moores Cancer Center.  Just looking through the post titles on the right/bottom… Read More

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